Testing Types
Wet Chemistry Testing

Wet Chemistry Testing

Classical and quantitative chemical testing methods used to evaluate pharmaceutical materials, verify quality attributes, and support regulatory compliance throughout the product lifecycle.

Terms and Conditions

I. Confidentiality:

PLS Analytical ("PLSA") maintains strict confidentiality with its clients.

Formal Confidentiality agreements may be initiated by the client or by PLS Analytical.

II. Financial Information

Payment in advance is required for clients whose credit has not been established with PLSA.
Payment terms are “NET 15 days from receipt of the results”. Buyer agrees to pay all costs, including, but not limited to attorney and accounting fees and other expenses of collection resulting from any default by buyer in any of the terms of this contract.
Purchase orders or valid credit card information are REQUIRED. Orders submitted without this information may cause delays in testing.
For third party billing a signed purchase order must be received from the party paying for the service.
A surcharge of 50% or greater will be added for EXPRESS service. Express is subject to prior approval and availability.
Pricing is designed for single samples. Project discounts may be available. Quotations will be provided free of charge.
A minimum billing of $25.00 will be charged on all samples including those samples cancelled at the customer's request.
Clients that request Raw Data will have a copy sent to them electronically (at no charge) along with their report. There may be a surcharge for copies of the raw data and report when requested after initial sending is completed.
Additional charges may be assessed (e.g. hazardous samples, composite fee).
Shipping costs will be charged to clients that would like containers, coolers or ice packs returned.
Liability of PLSA is limited to an amount no greater than the amount invoiced.

III. Sample Submission:

Fill out the Sample Submission Form COMPLETELY, including product name, lot number, test, methods, and the amount of samples sent. Incomplete information may cause a delay in providing services.
All results will be reported by the method supplied and/or identified. If a limit is not supplied, we will default to associated compendia limits, or “Report Results” when compendial limits are not available.
All samples should be labelled with company name, product name and lot number. Samples received without a lot number will be sent back to the client for proper labeling. Hazardous Substances must be appropriately labeled for the protection of office and laboratory personnel.
- Shipping carton exterior must be labeled as to the hazard enclosed; caustic, cytotoxic, antineoplastic, explosive, corrosive, toxic, or carcinogenic, etc.
- Safety Data Sheet (SDS) must be provided for all Hazardous samples.
- Additional charges may be applied.
- Please place Sample Submission Form, SDS and any other correspondence submitted, in an envelope and place at the top of the box or affixed to the outside of the box. Failure to use the PLSA Submission Form for Analytical Services may delay results.

IV. Retention and Disposal:

Samples are retained for a period of 30 days after completion of analysis.
Special PRIOR arrangements must be made to return or retain samples under other conditions.
Unless alternate arrangements have been made, raw data will be retained for 6 years after final report date.

IMPORTANT

Turnaround Times:
- In calculating turnaround times, pending all appropriate documentation is in order; if the sample is received before 10 am then the day the sample is received is Day 1 otherwise it will be on the next business day.
- Standard TAT is 10 Business days.
- Express Service is subject to prior approval, availability and surcharges.
- For International orders, please allow sufficient time for samples to clear customs.
Please pack samples appropriately to prevent breakage.
Because transportation of materials to our facilities can have significant impact on the moisture content of client sample materials, PLS Analytical will not accept client-provided Loss on Drying/Moisture content results. When required for testing, the Loss on Drying/Moisture Content will be performed at PLS Analytical and will be billed to clients at a flat rate. Please contact our Customer Service Team for current associated costs.
If growth is obtained during microbial enrichment testing, a gram stain will be performed and billed to the client. Please contact our Customer Service Team for current associated costs.
For Questions regarding the above information please contact our Client Services Department at 732-698-5050.

I confirm that I have read and accept the terms and conditions.

Sample Submission Form

Submitter Information

Date

Company Name / Address

Contact Name

Billing

Send Invoice To

If differentSame as Report

Name and email for invoicing

Order References

PO Number*

Quote Number*

Turn Around Time

StandardRush

Express, needed byInclude Raw Data

Controlled substance

Yes No

Microbiology sample suitability

YesNo

Analytical sample: method verification required

YesNo

Special Instructions

Fill The Sample Columns

SAMPLE NAME	LOT # (ONE LOT PER LINE)	METHOD (MUST BE PROVIDED)	TEST REQUESTED (MUST BE PROVIDED)	SPECIFICATION (MUST BE PROVIDED)	QUANTITY

Required for Testing to Begin Customer Initials and Date

Overview

What is Wet Chemistry?

Wet chemistry comprises a range of classical analytical techniques used to evaluate the identity, composition, purity, and quality of pharmaceutical materials through established chemical reactions and laboratory procedures. At PLS Analytical, these methods continue to play an important role in supporting pharmaceutical quality programs, particularly where compendial and regulatory requirements specify classical analytical approaches.

What is Wet Chemistry Testing?

PLS Analytical performs wet chemistry testing to assess critical quality attributes across raw materials, intermediates, finished products, water systems, and manufacturing processes. Our capabilities include titrations, gravimetric analysis, pH determination, moisture analysis, chemical assays, residue evaluations, and other compendial techniques that support formulation development, cleaning validation, stability studies, release testing, and routine quality control.

Why it Matters

Many critical quality attributes cannot be fully evaluated through instrumental analysis alone and require established wet chemistry techniques to generate accurate, reliable results. These studies help manufacturers verify product specifications, support manufacturing consistency, and maintain confidence in product quality throughout development and commercial production.

PLS Analytical delivers scientifically rigorous wet chemistry testing aligned with USP, EP, and global pharmacopeial standards, helping manufacturers generate reliable data for quality systems, regulatory submissions, and ongoing compliance.

Testing Services

Generate reliable chemical quality data across pharmaceuutical materials and products

PLS Analytical performs wet chemistry testing to support product development, material qualification, quality control programs, validation activities, and regulatory compliance requirements.

1. Chemical Assays & Quantitative Analysis

Chemical assays and quantitative analysis evaluate the concentration and composition of pharmaceutical materials using validated analytical procedures. Scientifically robust data supports raw materials, APIs, finished pharmaceutical products, routine quality control, and regulatory compliance.

2. Titration & Chemical Characterization

Titration and chemical characterization evaluate critical chemical properties using established wet chemistry techniques. Scientifically robust data supports raw material qualification, process monitoring, pharmacopeial testing, chemical characterization, and quality assurance.

3. pH, Moisture & Physical-Chemical Testing

pH, moisture, and physical-chemical testing evaluate critical quality attributes that influence product performance and manufacturing consistency. Scientifically robust data supports stability programs, manufacturing support, product release testing, process control, and lifecycle quality management.

Advantages

Built for reliable, scientifically established quality assessment

Wwet chemistry testing provides dependable analytical data that supports product quality, manufacturing consistency, and regulatory compliance.

Proven Analytical Methodologies

Established wet chemistry techniques have a long history of use across pharmaceutical quality systems and continue to serve as foundational tools for analytical evaluation.

Comprehensive Quality Assessment

Testing supports evaluation of multiple critical quality attributes, helping manufacturers develop a more complete understanding of product and material characteristics.

Versatile Application Across the Product Lifecycle

Wet chemistry methods can be applied from raw material qualification through commercial manufacturing, providing valuable data at every stage of development and production.

Regulatory Compliance

Wet chemistry testing supports compliance with USP, EP, FDA, and global pharmaceutical quality standards. Testing documentation can support release programs, validation activities, inspections, audits, regulatory submissions, and ongoing quality management initiatives.

Loading...